Why the study?
What are the survival outcomes and prognostic indicators in patients with second and subsequent osteosarcoma recurrences?
What are the survival outcomes and prognostic indicators in patients with second and subsequent osteosarcoma recurrences?
Surgical clearance is of overwhelming importance for survival in patients with second and subsequent osteosarcoma recurrences.
May warrant prioritizing surgical clearance in recurrent osteosarcoma; extends first-recurrence prognostic models but remains hypothesis-generating.
To our knowledge, this is the first report of survival estimates derived from large cohorts of unselected patients with second and subsequent osteosarcoma recurrences. It confirms the overwhelming importance of surgical clearance. Prognostic indicators after rerecurrences resemble those known from first recurrence. The exact role of re-treatment with chemotherapy, particularly in the adjuvant situation, remains to be defined.
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Bielack et al. (2008) studied this question.
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