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January 1, 1985European Paediatric Haematology and Oncology

Pulmonary metastases from osteogenic sarcoma: Complete resection and effective chemotherapy contributing to improved prognosis

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Why the study?

Does complete resection of pulmonary metastases and effective chemotherapy improve survival in patients with osteogenic sarcoma metastatic to the lung?

Population

54 unselected patients with osteogenic sarcoma metastatic to the lung from two successive prospective…

Comparison

Pulmonary surgery combined with chemotherapy. vs No pulmonary surgery (21 patients).

Design

Cohort

Follow-up

3 years (actuarial)

Authors

GBG. BeronHelios Hospital SchwerinAEAndré EulerCardiac ImagingKWK. WinklerBoston Children's Hospital

Discussion

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Implication

May support complete pulmonary metastasectomy in osteogenic sarcoma; hypothesis-generating and requires prospective validation.

Structured PICO

Does complete resection of pulmonary metastases and effective chemotherapy improve survival in patients with osteogenic sarcoma metastatic to the lung?

P
Population
54 unselected patients with osteogenic sarcoma metastatic to the lung (16 with synchronous pulmonary metastases and primary tumor, 38 developed pulmonary metastases during or after chemotherapy) from two successive prospective studies in Western Germany and Austria.
I
Intervention
Pulmonary surgery (one or more thoracotomies for resection of pulmonary metastases) combined with chemotherapy.
C
Comparator
No pulmonary surgery (21 patients).
O
Outcome
Actuarial three-year survival rate.hard clinical

Complete resection of pulmonary metastases combined with effective chemotherapy significantly improves survival in patients with osteogenic sarcoma metastatic to the lung.

Cite This Study

Beron et al. (1985) studied this question.

synapsesocial.com/papers/6a86663be3ff5bf5642ed17chttps://doi.org/10.3109/08880018509141211
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Osteogenic Sarcoma under the Age of Twenty-one1970 · 362 citations
  2. 2Lung resection for metastatic osteogenic sarcoma1978 · 13 citations
  3. 3Role of metastatectomy without chemotherapy in the management of osteosarcoma in children1980 · 35 citations
  4. 4Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study.1984 · 347 citations