December 2, 2013Annals of Internal Medicine
Are Metabolically Healthy Overweight and Obesity Benign Conditions?
Authors
Discussion
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Implication
Systematic review evaluates cardiovascular risk in metabolically healthy overweight individuals, indicating excess adiposity is not benign.
Key Points
- To determine whether metabolically healthy overweight and obesity represent benign conditions or confer elevated long-term cardiovascular and mortality risks.
- Evaluated clinical outcomes and disease risk across defined body mass index categories in the absence of baseline metabolic abnormalities.
- Conducted with intramural funding support from the Leadership Sinai Centre for Diabetes.
- Individuals with metabolically healthy overweight and obesity exhibit higher long-term risk of adverse cardiovascular outcomes and mortality than metabolically healthy normal-weight individuals.
- Qualitative synthesis indicates that excess adiposity remains hazardous over extended follow-up, challenging the notion of a completely harmless obese state.
Cite This Study
Kramer et al. (2013) studied this question.