Contribution of remnant cholesterol to cardiovascular risk
Why the study?
Does lower remnant cholesterol reduce recurrent MACE in individuals with a diagnosis of myocardial infarction or ischaemic stroke?
Population
Individuals with a diagnosis of myocardial infarction or ischaemic stroke
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for remnant cholesterol lowering in secondary prevention; randomized trials needed to confirm effects on recurrent MACE.
Structured PICO
Does lower remnant cholesterol reduce recurrent MACE in individuals with a diagnosis of myocardial infarction or ischaemic stroke?
P
Population
Individuals with a diagnosis of myocardial infarction or ischaemic stroke
I
Intervention
Lower remnant cholesterol of 0.8 mmol L-1 (32 mg dL-1)
O
Outcome
Recurrent MACEcomposite
Lowering remnant cholesterol may significantly reduce recurrent MACE in secondary prevention for patients with prior MI or ischemic stroke.
Cite This Study
Langsted et al. (2020) studied this question.