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December 7, 2006Proceedings of the National Academy of SciencesOpen Access

Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features

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Population

Calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain

Design

Preclinical

Authors

AHAnne HoudusseCentre National de la Recherche ScientifiqueJGJean‐François GaucherCentre National de la Recherche ScientifiqueEKElena B. KrementsovaHeart Failure / Cardiomyopathy

Discussion

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Implication

May inform myosin lever-arm models in muscle; leaves open relevance to human cardiac function.

Structured PICO

P
Population
Calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain
O
Outcome
Crystal structure at 2.5-A resolution

The crystal structure reveals essential recognition features of apo-calmodulin bound to IQ motifs, serving as a model for the lever arm region of unconventional myosins.

Cite This Study

Houdusse et al. (2006) studied this question.

synapsesocial.com/papers/69dbcb2b7d378569a9835d1ahttps://doi.org/10.1073/pnas.0609436103
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The CCP4 suite: programs for protein crystallography1994 · 17,396 citations
  2. 2AMoRe: an automated package for molecular replacement1994 · 4,957 citations
  3. 3Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin.1995 · 106 citations
  4. 4Myosin V2004 · 218 citations