November 7, 1995Proceedings of the National Academy of SciencesOpen Access

Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin.

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Population

Scallop myosin regulatory domain and calmodulin (CaM) superfamily

Design

Preclinical

Authors

AHAnne HoudusseCentre National de la Recherche Scientifique CCCarolyn CohenBrandeis University

Discussion

Member takes

Implication

Does not inform clinical myosin regulation; leaves open whether IQ constraints apply in human cardiac myosin.

Structured PICO

Population

Scallop myosin regulatory domain and calmodulin (CaM) superfamily

Intervention

Crystal structure analysis

Outcome

Target sequence recognition rules and structural constraints

This structural biology study reveals how the calmodulin superfamily binds to target peptides, highlighting the constraints imposed by the IQ motif in scallop myosin compared to the broader sequence accommodation of Ca(2+)-CaM.

Cite This Study

Houdusse et al. (1995) studied this question.

synapsesocial.com/papers/6a71dadeb5c1fe5ca9dfe7a6 https://doi.org/10.1073/pnas.92.23.10644

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Bookmark

Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider