Population
Scallop myosin and regulatory light chain (RLC) mutants/chimeras
Comparison
Mutations in the RLC vs Wild-type scallop RLC or unmutated skeletal RLC
Design
Preclinical
Authors
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No immediate clinical implications for human myosinopathies; leaves open functional conservation of G117 in vertebrate cardiac myosin.
The study demonstrates that a single glycine residue (G117) is critical for stabilizing the Ca2+-binding site and regulating ATPase activity in scallop myosin.
Jancsó et al. (1994) studied this question.
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