Gut Microbiota-Dependent Trimethylamine N -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

W.H. Wilson Tang; Zeneng Wang; David J. Kennedy; Yuping Wu; Jennifer A. Buffa; Brendan Agatisa-Boyle; Xinmin S. Li; Bruce S. Levison; Stanley L. Hazen

doi:10.1161/circresaha.116.305360

November 7, 2014Circulation ResearchOpen Access

Gut Microbiota-Dependent Trimethylamine N -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

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Key Points

To investigate the contribution of the gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway to chronic kidney disease progression and long-term mortality.
Measured plasma TMAO levels in patients with chronic kidney disease to evaluate associations with long-term survival.
Utilized animal models receiving chronic dietary exposures that elevate TMAO to assess direct effects on renal pathology.
Circulating plasma TMAO concentrations are significantly elevated in patients with chronic kidney disease and predict reduced long-term survival.
Dietary exposures elevating TMAO directly accelerate progressive renal fibrosis and functional decline in animal models.

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Implication

Translational study uncovers increased mortality and progressive renal fibrosis linked to elevated TMAO in chronic kidney disease, highlighting a gut-kidney axis.

Abstract

Plasma TMAO levels are both elevated in patients with CKD and portend poorer long-term survival. Chronic dietary exposures that increase TMAO directly contributes to progressive renal fibrosis and dysfunction in animal models.

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Cite This Study

Tang et al. (2014) studied this question.

synapsesocial.com/papers/69dbe164498b35d3e6a3d715 https://doi.org/10.1161/circresaha.116.305360

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Gut Microbiota-Dependent Trimethylamine N -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Key Points

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Implication

Abstract

Discussion

Cite This Study

Gut Microbiota-Dependent Trimethylamine N -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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