Key result
Trimethylamine N-oxide (TMAO) is an enteric-borne uremic toxin that plays a role in the progression of vascular calcification in patients with chronic kidney disease.
Why the study?
Vascular calcification is a common complication and major risk factor for cardiovascular mortality in CKD patients, but its pathology and pathogenesis are complex and not fully elucidated.
Design
Review
Authors
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TMAO may promote vascular calcification in CKD; leaves open whether targeting it alters outcomes.
This review highlights the role of TMAO in the progression of vascular calcification in CKD patients and discusses potential diagnostic and treatment strategies.
Zhang et al. (2024) conducted a review in Chronic kidney disease with vascular calcification. Trimethylamine N-oxide (TMAO) was evaluated. Trimethylamine N-oxide (TMAO) is an enteric-borne uremic toxin that plays a role in the progression of vascular calcification in patients with chronic kidney disease.
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