Randomized trial compares treatment effects using various analyzation methods, implying enhanced accuracy in results.
We recommend that all randomized clinical trials with substantial lack of adherence or loss to follow-up are analyzed using different methods. These include an intention-to-treat analysis to estimate the effect of assigned treatment and 'as treated' and 'per protocol' analyses to estimate the effect of treatment after appropriate adjustment via inverse probability weighting or g-estimation.
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Hernán et al. (2011) studied this question.
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