August 11, 2022Journal of Applied Physiology
Limits to submaximal and maximal exercise in patients with hypertrophic cardiomyopathy
Why the study?
Patients with hypertrophic cardiomyopathy often have reduced exercise capacity, and it is unclear whether cardiovascular regulation during exercise is intact in these patients.
Does cardiovascular regulation during exercise differ in patients with hypertrophic cardiomyopathy compared to healthy controls and patients with left ventricular hypertrophy?
Population
16 patients with HCM, 16 participants with LVH, and 61 healthy controls
Comparison
Patients with HCM vs healthy controls vs participants with LVH
Design
Cross-sectional physiological study
Authors
Discussion
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Member takes
Implication
Blunted exercise hemodynamics in HCM may reflect impaired SV reserve; this Level 4 observation leaves open prognostic and therapeutic relevance.
Structured PICO
Does cardiovascular regulation during exercise differ in patients with hypertrophic cardiomyopathy compared to healthy controls and patients with left ventricular hypertrophy?
P
Population
16 patients with hypertrophic cardiomyopathy (HCM) (48 ± 7 yr, 44% female), 16 participants with left ventricular hypertrophy (LVH) but not HCM (49 ± 5 yr, 44% female), and 61 healthy controls (CON: 52 ± 5 yr, 52% female).
I
Intervention
Submaximal steady-state treadmill exercise followed by a maximal exercise test
C
Comparator
Healthy controls and participants with left ventricular hypertrophy (LVH) undergoing the same exercise protocol
O
Outcome
Relationship between cardiac output (Q̇c) and oxygen uptake (V̇o2), and stroke volume (SV) reserve during rest and exercisesurrogate
Patients with hypertrophic cardiomyopathy exhibit a blunted cardiac output response to exercise due to reduced stroke volume reserve, but often compensate by increasing peripheral oxygen extraction to maintain exercise capacity.
Cite This Study
MacNamara et al. (2022) studied this question.