Comparative animal study reveals higher ischemic brain injury and an incomplete circle of Willis in C57Black/6 versus SV-129 mice, indicating genetic background confounds stroke models.
C57Black/6 mice exhibit enhanced susceptibility to global cerebral ischemic injury, an incompletely formed circle of Willis, and augmented pial vessel dilation to ACh compared with SV-129 mice. Our findings suggest that strain differences may confound results when genetically engineered mice generated from more than a single background strain are used.
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Fujii et al. (1997) studied this question.
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