February 1, 2000Nucleic Acids ResearchOpen Access

Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment

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Structured PICO

Population

Various cell types (in vitro models)

Intervention

Bicistronic and monocistronic mRNAs containing the c-myc 5' UTR

Comparator

Human rhinovirus 2 (HRV2) IRES and encephalomyocarditis virus (EMCV) IRES

Outcome

c-myc protein synthesis and translation efficiencysurrogate

The study demonstrates that c-myc protein synthesis can occur via both cap-dependent and IRES-mediated mechanisms, with the latter being highly efficient but dependent on cell-type specific factors and a nuclear event.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Warrants caution extrapolating IRES activity across cell types; leaves open the unidentified nuclear event's role in disease models.

Cite This Study

M. Stoneley (2000) studied this question.

synapsesocial.com/papers/69dc1ba521d1c80c0f751cd9 https://doi.org/10.1093/nar/28.3.687

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Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment

Structured PICO

Discussion

Implication

Cite This Study

Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider