What question did this study set out to answer?

To determine whether weekend dosing of prednisone is as safe and effective as daily administration in preserving muscle strength and preventing body mass index increases in boys with Duchenne muscular dystrophy.

July 14, 2011NeurologyOpen Access

Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy

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Authors

DEDiana M. EscolarBoston Children's Hospital LHLauren P. HacheChildren's National PCPaula R. ClemensUniversity of Pittsburgh

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Implication

Randomized blinded trial reveals weekend prednisone matches daily dosing for strength preservation and body mass index in Duchenne muscular dystrophy, suggesting an effective alternative regimen.

Key Points

To determine whether weekend dosing of prednisone is as safe and effective as daily administration in preserving muscle strength and preventing body mass index increases in boys with Duchenne muscular dystrophy.
Randomized, blinded clinical trial conducted over a 12-month follow-up period.
Assessed weekend prednisone administration in comparison to a daily prednisone dosing protocol in boys with Duchenne muscular dystrophy.
Weekend prednisone provided Class I evidence of equivalent efficacy and safety compared to daily prednisone for muscle strength preservation over 12 months (numerical values not reported in abstract).
Weekend dosing successfully prevented increases in body mass index at levels comparable to daily dosing throughout the 12-month study period.

Cite This Study

Escolar et al. (2011) studied this question.

synapsesocial.com/papers/69dc1fba9ff18c6539751bf6 https://doi.org/10.1212/wnl.0b013e318227b164

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Implication

Randomized blinded trial reveals weekend prednisone matches daily dosing for strength preservation and body mass index in Duchenne muscular dystrophy, suggesting an effective alternative regimen.

Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

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