What question did this study set out to answer?

To determine whether acute kidney injury not requiring dialysis associates with heightened long-term mortality among patients who survive at least 90 days after discharge, independent of residual kidney function.

December 18, 2009Journal of the American Society of NephrologyOpen Access

Acute Kidney Injury Associates with Increased Long-Term Mortality

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Authors

JLJean‐Philippe LafranceCentre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal DMDonald R. MillerCross-Cutting Cardiology

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Implication

Retrospective cohort study reveals increased long-term mortality in hospitalized veterans surviving acute kidney injury, indicating elevated risk independent of residual kidney function.

Key Points

To determine whether acute kidney injury not requiring dialysis associates with heightened long-term mortality among patients who survive at least 90 days after discharge, independent of residual kidney function.
Retrospective cohort analysis of 864,933 hospitalized US veterans who survived at least 90 days after discharge.
Identified non-dialysis acute kidney injury (AKI) using peak-to-baseline serum creatinine ratios.
Estimated mortality risks using multivariable Cox regression adjusted for demographics, comorbidities, medications, admission diagnosis, stay length, mechanical ventilation, and postdischarge estimated GFR.
Among 864,933 hospitalized patients, 82,711 had AKI; during follow-up, 17.4% of 90-day survivors died (29.8% with AKI vs 16.1% without AKI).
Adjusted long-term mortality risk associated with AKI was HR 1.41 (95% CI, 1.39 to 1.43).
Mortality risk increased progressively across AKI severity stages: stage 1 HR 1.36 (95% CI, 1.34 to 1.38), stage 2 HR 1.46 (95% CI, 1.42 to 1.50), and stage 3 HR 1.59 (95% CI, 1.54 to 1.65; P < 0.001 for trend).

Cite This Study

Lafrance et al. (2009) studied this question.

synapsesocial.com/papers/69dc241ed3349dba34751b9d https://doi.org/10.1681/asn.2009060636

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Implication

Retrospective cohort study reveals increased long-term mortality in hospitalized veterans surviving acute kidney injury, indicating elevated risk independent of residual kidney function.

Acute Kidney Injury Associates with Increased Long-Term Mortality

Discussion

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Implication

Key Points

Cite This Study

Acute Kidney Injury Associates with Increased Long-Term Mortality

Discussion

Member takes

Implication

Key Points

Cite This Study

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