Why the study?
Are recurrent hospitalizations associated with increased mortality across the ejection fraction range in heart failure?
Are recurrent hospitalizations associated with increased mortality across the ejection fraction range in heart failure?
Recurrent hospitalizations are associated with increased mortality regardless of ejection fraction phenotype, highlighting the importance of therapies that reduce hospitalizations.
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Recurrent hospitalizations associate with higher mortality across LVEF; supports phenotype-agnostic prevention trials but leaves causality open.
These findings suggest that disease progression, in terms of increased frequency of hospitalizations, and the relationship between increased number of hospitalizations and mortality are similar by LVEF phenotypes. These data highlight the importance of effective treatments that can reduce hospitalizations and suggest a role for monitoring NT-proBNP levels in the management of HFpEF patients in particular.
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Huusko et al. (2020) studied this question.
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