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October 18, 2011The American Journal of Gastroenterology

The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype

Nathalie Bertiaux-Vandaële Stéphanie Beutheu Youmba Liliana Belmonte Stéphane Lecleire Michel Antonietti Guillaume Gourcerol Anne‐Marie Leroi Pierre Déchelotte Jean-François Ménard Philippe Ducrotté Moı̈se Coëffier

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Abstract

Occludin and claudin-1 appeared markedly affected in IBS-D patients. In addition, our results suggest that alteration of TJ proteins may be involved in the initiation of IBS and contribute to visceral hypersensitivity.

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Bertiaux-Vandaële et al. (2011) studied this question.

synapsesocial.com/papers/69dc443a4f901957bec0ff53 https://doi.org/10.1038/ajg.2011.257

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Intestinal permeability and irritable bowel syndromeReview · 2007 · 145 citations
2Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel SyndromesCase-Control Study · 2006 · 478 citations
3Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute <i>Campylobacter</i> enteritis and in post-dysenteric irritable bowel syndromeOriginal Research · 2000 · 1,156 citations
4Intestinal membrane permeability and hypersensitivity in the irritable bowel syndromeOriginal Research · 2009 · 373 citations
5Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediatorsCase-Control Study · 2008 · 539 citations

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