What question did this study set out to answer?

To determine whether macrophage developmental origins influence their functional education within brain malignancies and assess whether bone-marrow-derived macrophages infiltrate primary and metastatic brain tumors.

November 1, 2016Cell ReportsOpen Access

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

View Full Paper

Ask AI

Bookmark

Authors

RBRobert L. BowmanUniversity of Pennsylvania FKFlorian KlemmSophia Genetics (France)LALeila AkkariThe Netherlands Cancer Institute

Discussion

Member takes

Implication

Lineage tracing study demonstrates distinct tumor education between microglia and recruited macrophages in brain malignancies, highlighting CD49D as a discriminatory marker.

Key Points

To determine whether macrophage developmental origins influence their functional education within brain malignancies and assess whether bone-marrow-derived macrophages infiltrate primary and metastatic brain tumors.
Utilized multiple mouse models of primary brain tumors and brain metastases.
Performed non-irradiation genetic lineage tracing to track macrophage populations without confounding radiation-induced artifacts.
Bone-marrow-derived macrophages (BMDMs) infiltrated extensively and were abundant in both primary and metastatic brain malignancies.
Brain-resident microglia and recruited BMDMs activated distinct transcriptional networks upon tumor exposure, which were constrained by pre-existing chromatin landscapes.
Microglia specifically repressed Itga4 (CD49D), establishing CD49D as a clear discriminatory marker between microglia and BMDMs across mouse and human brain malignancies.

Cite This Study

Bowman et al. (2016) studied this question.

synapsesocial.com/papers/69dc60c8d4d0de07d11332b7 https://doi.org/10.1016/j.celrep.2016.10.052

View Full Paper

Ask AI

Bookmark

Implication

Lineage tracing study demonstrates distinct tumor education between microglia and recruited macrophages in brain malignancies, highlighting CD49D as a discriminatory marker.

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

Discussion

Member takes

Implication

Key Points

Cite This Study

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider