Why the study?
Does prehospital fibrinolysis with timely coronary angiography improve effective reperfusion compared to primary PCI in patients with early STEMI who could not undergo primary PCI within 1 hour after the first medical contact?
Does prehospital fibrinolysis with timely coronary angiography improve effective reperfusion compared to primary PCI in patients with early STEMI who could not undergo primary PCI within 1 hour after the first medical contact?
Prehospital fibrinolysis with timely coronary angiography is an effective reperfusion strategy for early STEMI patients unable to receive primary PCI within 1 hour, despite a slightly increased risk of intracranial bleeding.
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Provides reperfusion alternative for early STEMI when primary PCI delayed >1 h; extends randomized evidence for prehospital fibrinolysis strategies.
Prehospital fibrinolysis with timely coronary angiography resulted in effective reperfusion in patients with early STEMI who could not undergo primary PCI within 1 hour after the first medical contact. However, fibrinolysis was associated with a slightly increased risk of intracranial bleeding. (Funded by Boehringer Ingelheim; ClinicalTrials.gov number, NCT00623623.).
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Armstrong et al. (2013) studied this question.
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