Preclinical study demonstrates selective cytotoxicity against lung cancer cells without harming normal cells, highlighting a novel hybrid drug design strategy.
Background The design and synthesis of hybrid molecules will explore finding new drugs. Objectives The synthesized hybrid molecules to evaluate their biological properties. Methods Apply click chemistry to tether flavonols and benzenesulfonamide. Results Two drug candidates show potential against lung cancer. Conclusions Two drug candidates did not affect the normal cells and provided a new drug design route.
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Chen et al. (2023) studied this question.
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