Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026Vietnam Journal of Chemistry

Design, Synthesis, Cytotoxicity, ADMET, and Molecular Docking Insights of Novel Bis ‐1,2,3‐Triazole‐Pyrimidinone Fused Compounds

View Full Paper
Ask AI
Bookmark
Share

Authors

CSChandrasekhar SomsoleVNVenkatathri NarayananVSVenugopal Singamaneni

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates anticancer activity in human lung and breast cancer cells, suggesting novel therapies.

Key Points

  • This research aims to design and synthesize novel bis‐1,2,3‐triazole‐pyrimidinone compounds and evaluate their anticancer properties.
  • Synthesis involved tosylation, Hantzsch reaction, and CuAAC reactions.
  • Characterization with NMR spectroscopy and high-resolution mass spectrometry.
  • Anticancer activity assessed using the MTT assay against various cancer cell lines.
  • Key compounds 8g and 8i exhibited significant cytotoxic activity against NCI-H69 and MCF7 with IC50 values of 5.14 µM and 4.63 µM, respectively.
  • Compounds showed no toxicity at effective concentrations.
  • Molecular docking indicated favorable interactions with cytochrome P450 2A13 with binding energies ranging from −5.83 to −6.80 kcal mol−1.

Cite This Study

Somsole et al. (2026) studied this question.

synapsesocial.com/papers/6a3f694caea7db3c19540155https://doi.org/10.1002/vjch.70160
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design, synthesis, and in silico studies of novel hybrid structures based on pyrimido-benzimidazole and 1,2,3-triazoles targeting oncogenic tyrosine kinases2026
  2. 2Synthesis, spectral analysis and in vitro anticancer activity of 1,2,3 triazole derivatives and their molecular docking studies2024 · 3 citations
  3. 3Quinazolinone‐1,2,3‐triazole Hybrid Compounds: Design, Synthesis, Molecular Docking, Cytotoxic Evaluation, and Photophysical Insights2026
  4. 4Synthesis of Benzimidazole Based 1,2,4‐Triazole Derivatives as Potential Anticancer Agents: <i>In Silico</i> Techniques2024 · 4 citations
  5. 5New hybrid pyridine–1,2,4-triazole scaffolds: synthesis, in vitro evaluation of anticancer and antimicrobial activity, and in silico insights2026 · 1 citations