What question did this study set out to answer?

To evaluate the age-stratified prevalence of traditional atherosclerotic risk factors and determine their relative prognostic impact on clinical presentation and in-hospital mortality in patients undergoing percutaneous coronary intervention.

October 18, 2023SHILAP Revista de lepidopterologíaOpen Access

Age‐Stratified Prevalence and Relative Prognostic Significance of Traditional Atherosclerotic Risk Factors: A Report from the Nationwide Registry of Percutaneous Coronary Interventions in Japan

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Why the study?

The prevalence of traditional atherosclerotic risk factors and their association with clinical profiles or mortality in percutaneous coronary intervention remained unclear.

What is the age-stratified prevalence and relative prognostic significance of traditional atherosclerotic risk factors in patients undergoing initial PCI?

Key Points

To evaluate the age-stratified prevalence of traditional atherosclerotic risk factors and determine their relative prognostic impact on clinical presentation and in-hospital mortality in patients undergoing percutaneous coronary intervention.
Analyzed 559,452 patients who underwent initial percutaneous coronary intervention between 2012 and 2019 in Japan using a nationwide registry.
Assessed traditional atherosclerotic risk factors (male sex, hypertension, dyslipidemia, diabetes, smoking, and chronic kidney disease) using logistic regression, relative risk models, and machine learning to compute relative contribution metrics.
Smoking was most strongly associated with acute myocardial infarction (adjusted OR, 1.62 [95% CI, 1.60–1.64]; RC, 47.1%) and premature coronary artery disease (adjusted beta, 2.68 [95% CI, 2.65–2.71]; RC, 42.2%), whereas diabetes was most strongly associated with multivessel disease (adjusted beta, 0.068 [95% CI, 0.066–0.070]; RC, 59.4%).
Absence of dyslipidemia showed the strongest association with cardiogenic shock (adjusted OR, 0.62 [95% CI, 0.61–0.64]; RC, 34.2%) and in-hospital mortality (adjusted OR, 0.44 [95% CI, 0.41–0.46]; RC, 39.8%).

Structured PICO

What is the age-stratified prevalence and relative prognostic significance of traditional atherosclerotic risk factors in patients undergoing initial PCI?

Population

559,452 patients who underwent initial percutaneous coronary intervention between 2012 and 2019 in Japan

Intervention

Presence of traditional atherosclerotic risk factors (male sex, hypertension, dyslipidemia, diabetes, smoking, and chronic kidney disease)

Outcome

Clinical profile (acute myocardial infarction, premature coronary artery disease, multivessel disease, cardiogenic shock) and in-hospital mortalityhard clinical

In patients undergoing initial PCI, traditional atherosclerotic risk factors have varying age-specific prevalence and distinct impacts on clinical presentation and in-hospital mortality.

Discussion

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Implication

These observational associations in initial PCI patients should not change practice; hypothesis-generating for age-specific risk stratification.

Cite This Study

Kanenawa et al. (2023) studied this question.

synapsesocial.com/papers/69dcc2c9c099bcfdbb1334e0 https://doi.org/10.1161/jaha.123.030881

Topics

Percutaneous coronary intervention Lipid management

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Implication

These observational associations in initial PCI patients should not change practice; hypothesis-generating for age-specific risk stratification.

Age‐Stratified Prevalence and Relative Prognostic Significance of Traditional Atherosclerotic Risk Factors: A Report from the Nationwide Registry of Percutaneous Coronary Interventions in Japan

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Age‐Stratified Prevalence and Relative Prognostic Significance of Traditional Atherosclerotic Risk Factors: A Report from the Nationwide Registry of Percutaneous Coronary Interventions in Japan

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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