Lifetime risk of developing coronary heart disease
Key result
Forty-year-old men face a ~53% higher lifetime risk of CHD than women.
- 95% CI 45.8-51.3 (men), 29.2-34.2 (women)
- n=7,733
Population
7,733 participants in the Framingham Heart Study, examined at least once at age 40-94 years between 1971 and…
Design
Cohort
Follow-up
109,948 person-years total
Authors
Discussion
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Overview
Highlights substantial lifetime CHD burden from age 40; extends observational risk data but leaves open effects of modern prevention.
Study Design
Type
Cohort (n=7,733)
Structured PICO
P
Population
7,733 participants aged 40-94 years, free of coronary heart disease at baseline, followed for a total of 109,948 person-years.
O
Outcome
Lifetime risk of coronary heart disease (composite of angina pectoris, coronary insufficiency, myocardial infarction, or death from coronary heart disease)composite
Main Result
Absolute Event Rate: 48.6% vs 31.7%
The lifetime risk of developing coronary heart disease at age 40 is approximately 1 in 2 for men and 1 in 3 for women, highlighting the substantial population burden of the disease.
Cite This Study
Lloyd‐Jones et al. (1999) conducted a cohort in Coronary heart disease (n=7,733). Male sex vs. Female sex was evaluated on Lifetime risk of coronary heart disease (angina pectoris, coronary insufficiency, myocardial infarction, or death from coronary heart disease) at age 40 years (95% CI 45.8-51.3 (men), 29.2-34.2 (women)). Men at age 40 years had a lifetime risk of developing coronary heart disease of 48.6% (95% CI 45.8-51.3), compared to 31.7% (95% CI 29.2-34.2) for women.