Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 17, 2005AJP Heart and Circulatory Physiology

Functional adaptation and remodeling of pulmonary artery in flow-induced pulmonary hypertension

View Full Paper
Ask AI
Bookmark
Share

Population

Rats with aortocaval fistula (model of high pulmonary blood flow/pulmonary hypertension)

Comparison

Aortocaval fistula surgery to induce high… vs Sham-operated animals

Design

Preclinical

Follow-up

8 weeks

Authors

CLChen-Fuh LamBuddhist Tzu Chi Medical FoundationTPTimothy E. PetersonUniversity of Missouri–St. LouisACAnthony J. CroattMayo Clinic

Discussion

Loading...

Member takes

Implication

Should not change clinical management of pulmonary hypertension; hypothesis-generating for prostanoid-NO interactions in high-flow models.

Structured PICO

P
Population
Rats with aortocaval fistula (model of high pulmonary blood flow/pulmonary hypertension)
I
Intervention
Aortocaval fistula surgery to induce high pulmonary blood flow
C
Comparator
Sham-operated animals
O
Outcome
Morphological changes of the pulmonary artery and vasomotor functionsurrogate

High pulmonary blood flow in rats causes pulmonary hypertension with abnormal vasomotor function mediated by reduced NO availability and high production of vasoconstrictor prostanoids.

Cite This Study

Lam et al. (2005) studied this question.

synapsesocial.com/papers/69dcc72f89c4deb67d359cd8https://doi.org/10.1152/ajpheart.00375.2005
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for Dysregulation of Dimethylarginine Dimethylaminohydrolase I in Chronic Hypoxia–Induced Pulmonary Hypertension2003 · 123 citations
  2. 2Upregulation of Renal and Vascular Nitric Oxide Synthase in Young Spontaneously Hypertensive Rats1998 · 243 citations
  3. 3Plasma thromboxane B2 concentration in pulmonary hypertension associated with congenital heart disease.1994 · 48 citations
  4. 4Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue2003 · 355 citations