Population
10 fetal lambs with in utero placement of an aortopulmonary vascular graft (shunt) and age-matched controls
Comparison
In utero placement of an aortopulmonary vascular… vs Age-matched controls
Design
Preclinical
Follow-up
4 weeks of age
Authors
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Early eNOS upregulation in high-flow shunt model; leaves open translational relevance to human congenital heart disease.
In a lamb model of congenital heart disease with increased pulmonary blood flow, there is an early upregulation of eNOS gene expression and activity.
Black et al. (1998) studied this question.
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