Why the study?
Does in utero placement of an aortopulmonary shunt alter cGMP, sGC, PDE5, and BNP levels in lambs?
Population
Lambs, from birth until 8 weeks of age, used as an animal model of a congenital cardiac defect with…
Comparison
In utero placement of an 8 mm aortopulmonary… vs Normal age-matched control lambs.
Design
Preclinical
Follow-up
8 weeks
Authors
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Elevated cGMP in this lamb shunt model extends preclinical understanding of NO signaling; leaves open translation to human congenital heart defects.
Does in utero placement of an aortopulmonary shunt alter cGMP, sGC, PDE5, and BNP levels in lambs?
In a lamb model of congenital heart defect with increased pulmonary blood flow, aortopulmonary shunting leads to elevated cGMP, sGC, PDE5, and BNP levels.
Oishi et al. (2007) studied this question.
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