Population
10 fetal lambs with in utero placement of an aortopulmonary vascular graft and control lambs, assessed at…
Comparison
In utero placement of an aortopulmonary vascular… vs Control lambs without shunt
Design
Preclinical
Follow-up
4-6 weeks of age
Authors
Loading...
Pulmonary arterial endothelial impairment may occur with high flow in shunt models; hypothesis-generating for mechanisms in congenital heart disease.
Increased pulmonary blood flow in a lamb model induces an impairment of endothelium-dependent relaxation selective to pulmonary arteries, potentially mediated by excess superoxide production.
Steinhorn et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: