Why the study?
Does NOS-derived reactive oxygen species alter relaxation of pulmonary arteries in a lamb model of increased pulmonary blood flow?
Population
12 fetal lambs with in utero placement of an aortopulmonary vascular graft to model increased pulmonary…
Comparison
In vitro application of pharmacological agents… vs Pulmonary arteries isolated from twin control…
Design
Preclinical
Follow-up
4-6 weeks of age
Authors
Loading...
Hypothesis-generating for NOS-derived superoxide impairing pulmonary relaxation in high-flow models; human studies needed before clinical relevance.
Does NOS-derived reactive oxygen species alter relaxation of pulmonary arteries in a lamb model of increased pulmonary blood flow?
In a lamb model of increased pulmonary blood flow, nitric oxide synthase catalyzes the production of superoxide anions, altering the redox environment and impairing pulmonary vascular relaxation.
Lakshminrusimha et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: