Population
Pulmonary artery endothelial or smooth muscle cells; 4-week old lambs with increased pulmonary blood flow…
Comparison
Endogenous activation of cGMP, exogenous… vs Untreated cells or lambs
Design
Preclinical
Follow-up
24 hours (for inhaled NO exposure)
Authors
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May underlie vascular dysfunction despite cGMP elevation in pulmonary hypertension; hypothesis-generating for antioxidant strategies in animal models.
Vascular dysfunction in pulmonary hypertension can occur despite elevated cGMP levels due to peroxynitrite-mediated PKG-1α nitration and subsequent attenuation of its kinase activity.
Aggarwal et al. (2011) studied this question.
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