Identifies specific macrophage subpopulation shifts, specifically increased CCR2+ monocytes and CD206+ macrophages, associated with myxomatous valve disease.
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Hypothesis-generating for immunomodulation in myxomatous valve disease; leaves open causal role and human relevance.
Our study demonstrates the heterogeneity of myeloid cells in heart valves and highlights an alteration of macrophage subpopulations, notably an increased presence of infiltrating CCR2+ monocytes and CD206+ macrophages, in myxomatous valve disease.
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Hulin et al. (2018) studied this question.
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