Population
Mice with cardiac-restricted knockout of connexin43 (Cx43) (n=28 observed)
Comparison
Cardiac-restricted inactivation/knockout of… vs Control littermates
Design
Preclinical
Follow-up
up to 2 months of age
Authors
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Cx43 loss drives uniform SCD in mice; leaves open whether gap junction remodeling contributes to human arrhythmogenesis.
Cardiac-specific loss of Cx43 in mice causes significant ventricular conduction slowing and uniform sudden cardiac death, establishing gap junction abnormalities as a key arrhythmogenic substrate.
Gutstein et al. (2001) studied this question.
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