Endothelial CNP acts on pericytes and microvascular SMCs via GC-B/cGMP signaling to regulate microcirculatory flow and maintain normal blood pressure.
Our studies indicate that endothelial CNP regulates distal arteriolar and capillary blood flow. CNP-induced GC-B/cGMP signaling in microvascular SMCs and pericytes is essential for the maintenance of normal microvascular resistance and blood pressure.
Špiranec et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: