Population
Microvascular smooth muscle cells (SMCs) and pericytes
Design
Preclinical
Authors
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Extends CNP/GC-B role to microvascular tone in animals; leaves open human relevance and therapeutic targeting.
Endothelial CNP acts on pericytes and microvascular SMCs via GC-B/cGMP signaling to regulate microcirculatory flow and maintain normal blood pressure.
Špiranec et al. (2018) studied this question.
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