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July 11, 2013Critical CareOpen Access

The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension

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Population

Arap1-deficient (Arap1-/-) and wildtype (+/+) mice, isolated perfused kidneys, and cultured mesangial cells

Comparison

Lipopolysaccharide injections to induce… vs Wildtype mice and baseline conditions

Design

Preclinical

Authors

KMKatharina MederleUniversity of RegensburgFSFrank SchwedaCzech Academy of Sciences, Institute of PhysiologyVKVeronika KattlerAIMM Therapeutics (Netherlands)

Discussion

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Implication

Identifies Arap1 as potential mediator of sepsis hypotension; hypothesis-generating for renin-angiotensin modulation in human shock.

Structured PICO

P
Population
Arap1-deficient (Arap1-/-) and wildtype (+/+) mice, isolated perfused kidneys, and cultured mesangial cells
I
Intervention
Lipopolysaccharide (LPS) injections (3 mg/kg) to induce endotoxemia, and incubation with pro-inflammatory cytokines (TNF-alpha, IFN-gamma)
C
Comparator
Wildtype mice and baseline conditions
O
Outcome
Mean arterial blood pressure (MAP) and vascular sensitivity to angiotensin IIsurrogate

Down-regulation of Arap1 expression during sepsis contributes to the development of hypotension by causing reduced vascular sensitivity to angiotensin II.

Cite This Study

Mederle et al. (2013) studied this question.

synapsesocial.com/papers/6a7591dde244091301600204https://doi.org/10.1186/cc12809
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mice Lacking Endothelial ACE2003 · 47 citations
  2. 2Angiotensin AT1receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II2012 · 18 citations
  3. 3Atrap Deficiency Increases Arterial Blood Pressure and Plasma Volume2010 · 54 citations
  4. 4Angiotensin Receptors and Their Therapeutic Implications1996 · 263 citations
  5. 5The Pathogenesis of Vasodilatory Shock2001 · 1,147 citations