February 23, 2012AJP Renal Physiology

Angiotensin AT1receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II

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Population

Mice (wild-type and eNOS-/-), cultured mesangial cells, and human kidney tissue

Comparison

Modulation of the renin-angiotensin system via… vs Control conditions

Design

Preclinical

Follow-up

up to 7 days

Authors

EDElisabeth DoblingerUniversity of Regensburg KHKlaus HöcherlFriedrich-Alexander-Universität Erlangen-Nürnberg KMKatharina MederleUniversity of Regensburg

Discussion

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Implication

Arap1 may modulate renal vascular AT1 signaling; leaves open its role in hypertension models.

Structured PICO

Population

Mice (wild-type and eNOS-/-), cultured mesangial cells, and human kidney tissue

Intervention

Modulation of the renin-angiotensin system via high-salt diet (4% NaCl), renal artery stenosis, water restriction, angiotensin II infusion (2 μg·kg(-1)·min(-1)), or AT1 antagonism (losartan 30 mg·kg(-1)·day(-1)) for up to 7 days

Comparator

Control conditions (0.6% NaCl diet, vehicle infusion, or baseline)

Outcome

Arap1 mRNA and protein expression levelssurrogate

Arap1 is highly expressed in the renal vasculature and its expression is suppressed by angiotensin II, suggesting it acts as a local modulator of vascular AT1 receptor function.

Cite This Study

Doblinger et al. (2012) studied this question.

synapsesocial.com/papers/6a7390bb427d94f6ee71b4d3 https://doi.org/10.1152/ajprenal.00620.2011

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Angiotensin AT1receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin AT1receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider