Why the study?
Does repeated exposure to transient obstructive sleep apnea-related conditions cause an atrial fibrillation substrate in a chronic rat model?
Does repeated exposure to transient obstructive sleep apnea-related conditions cause an atrial fibrillation substrate in a chronic rat model?
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Repeated exposure to transient OSA conditions in a rat model cumulatively leads to an AF substrate and increased AF susceptibility, suggesting mild-to-moderate OSA may require intensive management to prevent atrial remodeling.
Acute simulation of OSA was associated with reversible atrial oxidative stress. Cumulative exposure to these transient OSA-related conditions resulted in AF substrates and was associated with increased AF susceptibility. Mild-to-moderate OSA with high night-to-night variability may deserve intensive management to prevent atrial substrate development.
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Linz et al. (2020) studied this question.
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