November 1, 2017Circulation Arrhythmia and Electrophysiology127 citationsOpen Access
View Full PaperAtrial Substrate and Triggers of Paroxysmal Atrial Fibrillation in Patients With Obstructive Sleep Apnea
Key Result
Elimination of extra-pulmonary vein triggers in patients with paroxysmal atrial fibrillation and obstructive sleep apnea resulted in improved arrhythmia-free survival (P=0.003).
Study Design
Type
Observational
Structured PICO
Does elimination of extra-PV triggers improve arrhythmia-free survival in patients with paroxysmal AF and OSA?
P
Population
Patients with paroxysmal atrial fibrillation (AF) and obstructive sleep apnea (OSA)
I
Intervention
Elimination of extra-pulmonary vein (PV) triggers
O
Outcome
Arrhythmia-free survivalhard clinical
In patients with paroxysmal AF and OSA, who have increased extra-PV triggers, elimination of these triggers improves arrhythmia-free survival.
Main Result
p-value: p=0.003
Abstract
BACKGROUND: Obstructive sleep apnea (OSA) is associated with atrial remodeling, atrial fibrillation (AF), and increased incidence of arrhythmia recurrence after pulmonary vein (PV) isolation. We aimed to characterize the atrial substrate, including AF triggers in patients with paroxysmal AF and OSA. METHODS AND RESULTS: =0.003). CONCLUSIONS: OSA is associated with structural and functional atrial remodeling and increased incidence of extra-PV triggers. Elimination of these triggers resulted in improved arrhythmia-free survival.