Why the study?
Does streptokinase improve resolution compared to heparin in patients with isolated acute massive pulmonary embolism?
Does streptokinase improve resolution compared to heparin in patients with isolated acute massive pulmonary embolism?
Streptokinase provides significantly greater resolution of acute massive pulmonary embolism at 72 hours compared to heparin, though with a higher risk of bleeding at intervention sites.
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Streptokinase may accelerate early resolution in massive PE; leaves open net benefit versus modern anticoagulation pending RCTs.
Miller et al. (1971) studied this question.
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