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Multicenter study links the PAI-1 4G/5G polymorphism to increased risk of childhood-onset lupus and nephritis, suggesting a genetic driver of disease severity.
The PAI-1 4G/5G polymorphism may confer susceptibility to childhood-onset SLE and development of lupus nephritis among Egyptian children and adolescents. Moreover, the PAI-1 4G/4G genotype and 4G allele were associated with higher PAI-1 serum levels and higher disease activity scores.
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Yousef et al. (2020) studied this question.
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