Is HIV infection associated with abnormal myocardial function, steatosis, and fibrosis in adults without known cardiovascular disease?
Reduced myocardial function in HIV-infected adults without known CVD is associated with myocardial steatosis and diffuse fibrosis, highlighting potential metabolic and inflammatory therapeutic targets.
HIV-infected adults have reduced myocardial function as compared to controls in the absence of known CVD. Decreased cardiac function was associated with abnormal myocardial tissue composition characterized by increased lipid levels and diffuse myocardial fibrosis. Metabolic alterations related to antiretroviral therapy and chronic inflammation may be important targets for optimizing long-term cardiovascular health in HIV-infected individuals.
Thiara et al. (Mon,) studied this question.