What question did this study set out to answer?

Evaluate a novel radioligand for positron emission tomography (PET) quantification of cyclooxygenase-2 (COX-2) expression in primate neuroinflammation and assess its initial performance in humans.

May 2, 2020SHILAP Revista de lepidopterologíaOpen Access

PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

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Authors

SSSaurav ShresthaUniversity of Kansas MKMin-Jeong KimNational Institutes of Health MEMark A. G. EldridgeNational Institutes of Health

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Implication

Randomized trial demonstrates PET imaging of cyclooxygenase-2 in primate neuroinflammation and humans, indicating potential for tracking brain inflammation.

Key Points

Evaluate a novel radioligand for positron emission tomography (PET) quantification of cyclooxygenase-2 (COX-2) expression in primate neuroinflammation and assess its initial performance in humans.
Clinical trial registered under ClinicalTrials.gov NCT03912428 evaluating a novel radiotracer targeting cyclooxygenase-2.
Conducted PET imaging assessments in primate models of neuroinflammation alongside a first-in-human clinical protocol.
Demonstrated measurable upregulation of cyclooxygenase-2 via PET imaging during primate neuroinflammation.
Achieved successful first-in-human translation and characterization of the novel COX-2 radioligand.

Cite This Study

Shrestha et al. (2020) studied this question.

synapsesocial.com/papers/69dd45447808b00a4799bf80 https://doi.org/10.1186/s12974-020-01804-6

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Implication

Randomized trial demonstrates PET imaging of cyclooxygenase-2 in primate neuroinflammation and humans, indicating potential for tracking brain inflammation.

PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

Discussion

Member takes

Implication

Key Points

Cite This Study

PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

Discussion

Member takes

Implication

Key Points

Cite This Study

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