What question did this study set out to answer?

To determine whether isoflurane provides durable neurologic and histologic neuroprotection following focal cerebral ischemia under varying physiological conditions.

January 1, 2007AnesthesiologyOpen Access

Isoflurane Provides Long-term Protection against Focal Cerebral Ischemia in the Rat

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Authors

HSHiroaki SakaiNagoya City University HSHuaxin ShengDuke University RYRobert B. YatesUniversity of Washington

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Implication

Preclinical experimental study demonstrates long-term neurologic and histologic protection with isoflurane in rats with focal ischemia, indicating robust neuroprotective efficacy.

Key Points

To determine whether isoflurane provides durable neurologic and histologic neuroprotection following focal cerebral ischemia under varying physiological conditions.
Administered isoflurane in a rat model of focal cerebral ischemia across varying ischemia durations and perfusion pressures.
Evaluated the effect of pretreatment with 5-hydroxydecanoate on isoflurane-mediated outcomes.
Isoflurane repeatedly improved long-term neurologic function and reduced histologic injury following focal cerebral ischemia.
Neuroprotective benefits persisted independently of ischemia duration, perfusion pressure levels, or pretreatment with 5-hydroxydecanoate.

Cite This Study

Sakai et al. (2007) studied this question.

synapsesocial.com/papers/69dd46db8557d5ab8f40c7cf https://doi.org/10.1097/00000542-200701000-00017

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Implication

Preclinical experimental study demonstrates long-term neurologic and histologic protection with isoflurane in rats with focal ischemia, indicating robust neuroprotective efficacy.

Isoflurane Provides Long-term Protection against Focal Cerebral Ischemia in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Isoflurane Provides Long-term Protection against Focal Cerebral Ischemia in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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