Why the study?
Does isoflurane reduce myocardial infarct size in a rabbit model of ischemia and reperfusion injury?
Population
Rabbits (n=43) undergoing 30 min of coronary occlusion followed by 3 h of reperfusion
Comparison
Isoflurane administered 24 h before acute… vs 0.9% intravenous saline or celecoxib alone
Design
Preclinical, randomly assigned
Follow-up
3 hours of reperfusion
Authors
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Supports isoflurane preconditioning research in ischemia-reperfusion models; leaves open translation to human cardioprotection.
Does isoflurane reduce myocardial infarct size in a rabbit model of ischemia and reperfusion injury?
Isoflurane produces a delayed preconditioning effect against myocardial ischemia and reperfusion injury in rabbits, which is mediated by COX-2.
Tanaka et al. (2004) studied this question.
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