Why the study?
Do Cardiosphere-Derived Cells improve LV relaxation, LV diastolic pressure, and survival in a rat model of HFpEF?
Do Cardiosphere-Derived Cells improve LV relaxation, LV diastolic pressure, and survival in a rat model of HFpEF?
Cardiosphere-derived cells may offer a novel therapeutic approach for HFpEF by reversing inflammation and fibrosis, independent of blood pressure and hypertrophy.
CDCs normalized LV relaxation and LV diastolic pressure while improving survival in a rat model of HFpEF. The benefits of CDCs occurred despite persistent hypertension and cardiac hypertrophy. By selectively reversing inflammation and fibrosis, CDCs may be beneficial in the treatment of HFpEF.
No takes yet. Share an insight, caveat, or question.
Gallet et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: