The LKB1 knockout mouse model replicates the human AF disease process, highlighting inflammatory atrial cardiomyopathy as a key driver of electrical and structural remodeling.
LKB1 KO mice develop spontaneous AF from sinus rhythm and progress into persistent AF by replicating the human AF disease process. Progressive inflammatory atrial cardiomyopathy is the genesis of AF, through mechanistic electrical and structural remodeling.
Özcan et al. (Tue,) studied this question.