What question did this study set out to answer?

To outline how dysregulated extracellular matrix remodeling promotes fibrotic diseases and cancer progression, and to evaluate emerging models and technologies for therapeutic discovery.

February 16, 2011Disease Models & MechanismsOpen Access

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

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Authors

TCThomas R. CoxGarvan Institute of Medical Research JEJanine T. ErlerUniversity of Copenhagen

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Implication

Perspective review uncovers mechanisms of extracellular matrix dysregulation across fibrotic disorders and cancer, highlighting critical targets for disease modeling and therapeutic intervention.

Key Points

To outline how dysregulated extracellular matrix remodeling promotes fibrotic diseases and cancer progression, and to evaluate emerging models and technologies for therapeutic discovery.
Reviewed cellular and molecular mechanisms governing extracellular matrix (ECM) homeostasis and pathological remodeling in fibrosis and cancer.
Evaluated current in vitro and in vivo disease models alongside imaging and quantification techniques used to capture cell-ECM interactions.
Uncontrolled ECM remodeling drives fibrotic diseases—including pulmonary fibrosis, systemic sclerosis, and liver cirrhosis—that account for over 45% of deaths in the developed world.
Aberrant matrix remodeling critically enables tumor malignancy and metastatic progression, which together cause over 90% of cancer-related mortality.
Advancing clinical treatments requires integrated in vitro and in vivo models combined with quantitative imaging technologies to track dynamic matrix microenvironments.

Cite This Study

Cox et al. (2011) studied this question.

synapsesocial.com/papers/69dd4aec0644c7b49d40cabb https://doi.org/10.1242/dmm.004077

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Implication

Perspective review uncovers mechanisms of extracellular matrix dysregulation across fibrotic disorders and cancer, highlighting critical targets for disease modeling and therapeutic intervention.

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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