Why the study?
Diabetic cardiomyopathy is increasingly recognized as a cause of heart failure in diabetes mellitus, with several established and emerging mitochondrial mechanisms proposed to contribute to its development.
Design
Review
Authors
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Extends mechanistic understanding of diabetic cardiomyopathy; leaves open targeted therapies pending prospective validation.
This review outlines the complex mitochondrial mechanisms, such as energy depletion and oxidative stress, that contribute to the pathogenesis of diabetic cardiomyopathy.
Gollmer et al. (2020) studied this question.
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