Why the study?
Are trial characteristics and gender of trial leaders associated with under-enrolment of females in HFrEF RCTs?
Are trial characteristics and gender of trial leaders associated with under-enrolment of females in HFrEF RCTs?
Highlights persistent under-enrolment of females in HFrEF trials and identifies trial leadership gender and other characteristics as associated factors.
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Persistent female under-enrollment in HFrEF trials requires targeted recruitment strategies; confirms trial leadership gender and characteristics as modifiable factors.
Females were under-enrolled relative to disease distribution in a majority of high-impact HFrEF RCTs, with no change in temporal trends between 2000 and 2019. Trial characteristics and gender of trial leaders were associated with under-enrolment.
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Whitelaw et al. (2020) studied this question.
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