Increasing obesity severity in HFpEF is associated with worse hemodynamics and outcomes, though many patients retain preserved right heart function and may remain candidates for atrial shunt therapy.
Obesity severity may refine HFpEF prognosis and monitoring; extends hemodynamic associations but leaves open effects on shunt candidacy.
Increasing severity of obesity was associated with greater cardiac remodelling, higher right and left ventricular filling pressures, higher cardiac output and increased subsequent heart failure events. Despite significant obesity, many HFpEF patients have preserved right heart and pulmonary vascular function and thus, may be appropriate candidates for atrial shunt therapy.
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Litwin et al. (2023) studied this question.
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