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October 2, 2008Nucleic Acids ResearchOpen Access

ARDB--Antibiotic Resistance Genes Database

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Authors

BLBin LiuLuminex (United States)MPMihai PopUniversity of Maryland, College Park

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Implication

Bioinformatics database development uncovers curated resistance profiles across bacterial genomes, highlighting accessible surveillance for newly sequenced pathogens.

Key Points

  • To establish a centralized, manually curated repository unifying publicly available data on antibiotic resistance genes and resistance-conferring mutations.
  • Curated publicly available data on resistance genes, resistance profiles, mechanisms of action, and biological ontologies.
  • Integrated annotations from COG and CDD databases alongside external links to standard sequence and protein repositories.
  • Implemented computational tools for sequence similarity searches and the identification of known resistance mutations.
  • Compiled a comprehensive catalog detailing 13,293 resistance genes across 377 distinct resistance types and 257 antibiotics.
  • Indexed resistance data spanning 632 bacterial genomes, 933 species, and 124 genera into a publicly accessible web resource.

Cite This Study

Liu et al. (2008) studied this question.

synapsesocial.com/papers/69dd54894917c2595e100e0dhttps://doi.org/10.1093/nar/gkn656
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