Observational study demonstrates cerebrovascular dysregulation and neuropathy in hypermobile Ehlers-Danlos syndrome, highlighting mechanisms driving orthostatic intolerance.
This study provided evidence of cerebrovascular dysregulation with reduced orthostatic cerebral blood flow velocity associated with symptoms of cerebral hypoperfusion, frequent small fiber neuropathy, and widespread but mild autonomic failure in hEDS.
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Novák et al. (2025) studied this question.
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